Facilities of WRRC include analytical laboratories for environmental virology, water bacteriology, water quality, soil hydrology, and toxic chemicals. Access to other UH laboratory space can often be arranged as needed. Small research installations– such as the wind-powered desalination apparatus on Coconut Island, the University's marine biology facility–are located at numerous points around Oahu.

The WRRC library contains some 5,000 volumes on water resources, especially as related to Hawaii. It is a repository for the more than 400 reports produced by WRRC researchers since the Center's establishment.

The Center's offices, library and laboratories are located on the UH-Manoa campus, in Holmes Hall. Most faculty have offices with their instructional department.