Facilities of WRRC include well-equipped analytical laboratories for environmental virology, water bacteriology, water quality, soil hydrology, and toxic chemicals. Access to other UH laboratory space can often be arranged as needed. Small research installations are located at numerous points around Oahu.

The WRRC Analytical Laboratory is housed in 700 sq. ft. of space in the engineering building, Holmes Hall, room 181. WRRC works closely with the department of Civil and Environmental Engineering, and, together, they have furnished the laboratory with up-to-date, and state-of-the-art, equipment for the analysis of environmental pollutants at trace levels of parts per million (ppm), parts per billion (ppb), and even parts per trillion (ppt). This includes Volatile and Semi Volatile Organic compounds like Petroleum Hydrocarbons, Industrial Solvents, Explosives, Pharmaceuticals & Personal Care Products (PPCPs), and Endocrine Disruptors like Organochlorine Pesticides, Polychlorinated Biphenyls (PCBs), Polynuclear Aromatic Hydrocarbons (PAHs).

Extensively renovated and updated in 2004, WRRC's microbiology laboratory is capable of performing microbiological as well as some molecular biological analyses such as polymerase chain reaction (PCR). The lab is equipped with a PCR thermal cycler; electrophoresis equipment; and a low-pressure, low intensity UV, and a medium pressure, high-intensity UV, collimated beam unit (used to test the disinfection capabilities of ultraviolet light). Of course the lab is also equipped with the standard micro lab necessities (a biological safety hood, aerobic and anaerobic incubators, water baths, microscopes, membrane filtration apparatus, tabletop centrifuges, and storage refrigerators.) For rapid water quality testing to detect coliforms and E. coli, the Colilert system is used in this lab. Likewise, the Microtox bioassay testing system is used for toxicity screening of water samples (marine or fresh).

The WRRC library located in Holmes Hall 285, is a repository for the more than 400 reports produced by WRRC researchers since the Center's establishment.

The Center's offices, library and laboratories are located on the UH-Manoa campus, in Holmes Hall. Most faculty have offices with their instructional department.